loading page

Nosocomial infection of extensively drug-resistant Myroides odoratimimus in a Turkish hospital
  • +12
  • Unsal Savci,
  • Baris Eser,
  • Mustafa Sungur,
  • Mustafa Sahin,
  • Nezahat Kosar,
  • Djursun KARASARTOVA,
  • Ayse Semra GURESER,
  • Aysegul Taylan-Ozkan,
  • Selahattin Caliskan,
  • Serap Suzuk Yildiz,
  • Fatma Bayrakdar,
  • Yasemin Numanglu Cevik,
  • Coskun Kaya,
  • Derya Yapar,
  • Ozlem Akdogan
Unsal Savci
Hitit University
Author Profile
Baris Eser
Hitit University
Author Profile
Mustafa Sungur
Eskişehir State Hospital
Author Profile
Mustafa Sahin
Hitit University
Author Profile
Nezahat Kosar
Hitit University, Turkey
Author Profile
Djursun KARASARTOVA
Hitit Universitesi
Author Profile
Ayse Semra GURESER
Hitit University, Faculty of Medicine
Author Profile
Aysegul Taylan-Ozkan
Hitit University, Turkey
Author Profile
Selahattin Caliskan
Reyap Hospital, Department of Urology
Author Profile
Serap Suzuk Yildiz
Public Health Institutions of Turkey
Author Profile
Fatma Bayrakdar
Public Health Institutions of Turkey, Ankara, Turkey.
Author Profile
Yasemin Numanglu Cevik
Public Health Institutions of Turkey
Author Profile
Coskun Kaya
Eskisehir City Hospital, Department of Urology
Author Profile
Derya Yapar
Hitit University Faculty of Medicine,Turkey.
Author Profile
Ozlem Akdogan
Hitit University Faculty of Medicine,Turkey.
Author Profile

Abstract

Objectives: Myroides spp. is an environmental pathogen and causes disease in immunocompromised patients. In this study, we report an outbreak of urinary tract infections caused by M. odoratimimus in a university hospital in Turkey. Methods: A total of 25 M. odoratimimus strains isolated from the clinical samples of 20 patients in our intensive care units and clinics were included in the study. Phenotypic and genotypic identification of isolates was performed using conventional methods, VITEK®-2 automated identification system, Matrix Assisted Laser Desorption/Ionisation-Time of Flight Mass Spectrometry and 16S-RNA Microbial Diagnosis methods. In addition, Repetitive Extragenic Palindromic Elements (REP) PCR Assay method was applied for molecular epidemiological analysis. Results: All cases were diagnosed with nosocomial urinary tract infection, except for one case diagnosed with nosocomial bacteraemia. One of the M. odoratimimus isolates was sensitive to piperacillin/tazobactam (MIC: ≤4 µg/ml) and one isolate was moderately sensitive to cefepime (MIC: 16 µg/ml). Other M. odoratimimus isolates were resistant to the tested antibiotics of beta lactams, monobactams, carbapenems, aminoglycosides, fluoroquinolones and sulphonamides. When 10 isolates were evaluated with the REP PCR method, DNA finger print similarities were visually determined and there was a similar DNA pattern among them. Myroides source was not detected in environmental samples. Conclusion: Clinicians should consider that Myroides spp. isolates with multiple and broad-spectrum drug resistance may be a serious nosocomial pathogen like Pseudomonas aeruginosa or Acinetobacter baumannii. In order to choose the best treatment regimen, this atypical pathogen needs to be quickly identified and antibiotic susceptibility tests performed.

Peer review status:UNDER REVIEW

12 Oct 2020Submitted to International Journal of Clinical Practice
17 Oct 2020Assigned to Editor
17 Oct 2020Submission Checks Completed
19 Oct 2020Reviewer(s) Assigned